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(ie di erent selection methods, eg negative or clonal selection) The proposed multi-layered AIS consists of the following layers: the free-antibody layer (F), B-Cell layer (B) and the memory layer (M) The set of training patterns, DT , is seen as antigen Each layer has an a nity threshold (aF , aB , aM ), and a death threshold ( F , B , M ) The death threshold is measured against the length of time since a cell was last stimulated within a speci c layer If the death threshold does not exceed this calculated length of time, the cell dies and is removed from the population in the speci c layer The a nity threshold (aF , aB , aM ) determines whether an antigen binds to an entity within a speci c layer The a nity, fa , between an antigen pattern and an entity in a layer is measured using Euclidean distance Algorithm 194 summarizes the multi-layered AIS The di erent parts of the algorithm are discussed next An antigen, zp , rst enters the free-antibody layer, F In the free-antibody layer, the antigen pattern is then presented to nf free-antibodies The number of free-antibody bindings is stored in the variable nb The antigen, zp , then enters the B-Cell layer, B, and is randomly presented to the B-Cells in this layer until it binds to one of the B Cells After binding, the stimulated B-Cell, uk , produces a clone, uk , if the stimulation level exceeds a predetermined stimulation threshold, B The stimulation level is based on the number of free-antibody bindings, nb , as calculated in the free-antibody layer The clone is then mutated as uk and added to the B-Cell layer The stimulated BCell, uk , produces free antibodies that are mutated versions of the original B-Cell The number of free antibodies produced by a B-Cell is de ned in [468] as follows: fF (zp , uk ) = (amax fa (zp , uk )) (192).

where fF is the number of antibodies that are added to the free-antibody layer, amax is the maximum possible distance between a B-Cell and an antigen pattern in the data space (ie lowest possible a nity), fa (zp , uk ) is the a nity between antigen, zp , and B-Cell, uk , and is some positive constant If an antigen does not bind to any of the B-Cells, a new B-Cell, unew , is created with the same presentation as the unbinded antigen, zp The new B-Cell is added to the B-Cell layer resulting in a more diverse coverage of antigen data The new B-Cell, unew , also produces mutated free antibodies, which are added to the free-antibody layer The nal layer, M, consists only of memory cells and only responds to new memory cells The clone, uk , is presented as a new memory cell to the memory layer, M The memory cell with the lowest a nity to uk is selected as vmin If the a nity between k and vmin is lower than the predetermined memory threshold, aM , and the a nity u of uk is less than the a nity of vmin with the antigen, zp (that was responsible for the creation of the new memory cell, uk ), then vmin is replaced by the new memory cell, uk If the a nity between uk and vmin is higher than the predetermined memory threshold, aM , the new memory cell, uk , is added to the memory layer The multi-layered model improved the SSAIS model [626] (discussed in Section 194) in that the multi-layered model obtained better compression on data while forming stable clusters

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Although I refer to an MTM, developers should be aware that, in fact, an MTM comprises a number of parts: a server-side MTM is a plug-in derived from the CBaseServerMtm class that is loaded directly by the Message Server and is responsible for the actual message transport, such as sending and receiving, if applicable a client-side MTM is derived from the CBaseMtm class and provides an API for messaging clients, such as the Messaging Application, that are speci c to the message type a user interface MTM is derived from the CBaseMtmUi class and provides an API for use by a messaging application that has a user interface, making it easier to create a generic messaging application that can manage different types of message a user interface data MTM is derived from the CBaseMtmUiData class and encapsulates user interface data for the MTM such as icons for the Messaging Application.

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